The metabolic competition angle is fascinating - it's elegant how this leverages the body's own resource allocation rather than trying to poison cancer cells directly.
A few questions about the mechanism:
1. How selective is this approach? Cancer cells are notoriously heterogeneous - do different cancer types or subtypes respond differently to this metabolic pressure?
2. The cold exposure converting white to beige fat is interesting, but what about the feasibility for actual patients? Sustained cold exposure seems difficult to maintain for someone already dealing with cancer treatment.
3. Has anyone looked at whether this could work synergistically with existing metabolic therapies like metformin or ketogenic diets? The metabolic stress combined with nutrient competition could be powerful.
4. What's the risk of adaptive resistance? Cancer cells are remarkably good at finding alternative metabolic pathways when stressed.
RIP to Nguyen - it's heartbreaking when promising researchers pass before seeing their work come to fruition. Hope the team continues this line of investigation.
It’s CRISPR and injection changing their fat cells, not cold exposure. They theorized something in cold exposure modulated energy and fat, they found genes and tested which one works best via crispr, the ucp1
A few questions about the mechanism:
1. How selective is this approach? Cancer cells are notoriously heterogeneous - do different cancer types or subtypes respond differently to this metabolic pressure?
2. The cold exposure converting white to beige fat is interesting, but what about the feasibility for actual patients? Sustained cold exposure seems difficult to maintain for someone already dealing with cancer treatment.
3. Has anyone looked at whether this could work synergistically with existing metabolic therapies like metformin or ketogenic diets? The metabolic stress combined with nutrient competition could be powerful.
4. What's the risk of adaptive resistance? Cancer cells are remarkably good at finding alternative metabolic pathways when stressed.
RIP to Nguyen - it's heartbreaking when promising researchers pass before seeing their work come to fruition. Hope the team continues this line of investigation.