Most smokers actually don't die of lung cancer. I think it's something like only 15% of lifetime smokers get lung cancer?
They die of heart disease, mostly, which is caused by... drumroll please... prolonged nicotine use! At least, in part. It's actually more complicated and we don't know for sure.
I guess the question is, how does leaves in your lungs cause your blood vessels in your, say, legs, to get damaged? Makes no sense.
The answer is, probably, nicotine. We know, for sure, nicotine contracts blood vessels and raises blood pressure. And we know high blood pressure over time damages blood vessels.
You do realise whatever your blood absorbs in your lugs is distributed throughout your body? Some tissues will absorb certain types of chemicals more so than others.
You’re right though, nicotine is a CNS stimulant, which by definition does indeed constrict peripheral blood vessels, and raise blood pressure.
However, it is well documented that tobacco smoke contains many nastiest.
And well documented that wood smoke, and smoke from burning plant matter more generally, is a health hazard, and not just from the acute carbon monoxide risk.