MLX does not support the ANE.

https://github.com/ml-explore/mlx/issues/18

Yes it does.

That’s just an issue with stale and incorrect information. Here are the docs https://opensource.apple.com/projects/mlx/

No, it categorically doesn't. Not just that, it's CPU support is quite lacking (fp32 only). Currently, there are two ways to support the ANE: CoreML and MPSGraph.

Nothing in that documentation says anything about the Apple Neural Engine. MLX runs on the GPU.

None of that uses the ANE.

It does indeed, and is more modern than Core ML.