Specifically, if your work is a typical job, it makes your meaning dependent on a business relationship where one side has a lot more power than the other side. Example: an employer may end or modify the relationship for factors that are unrelated to your goals at any time.
In general, depending on work for one's ultimate meaning is dumb because whether or not you worked "hard enough" is judged by other people, not the entity responsible for putting humans (and therefore you) on the planet in the first place--you're already here so you obviously are supposed to be here, otherwise you wouldn't be. Good work makes you deserve to be among others but it can't make you deserve to exist on the planet.
>where one side has a lot more power than the other side
This is life, in its entirety. Even those who feel like they live a 'free' life should realize they depend on things like national security and access to healthcare, right? So the power dynamic there doesn't make sense to me, unless you're also constantly in fear of all these other systems falling apart. Humans have worked to earn money to live forever. There wouldn't be money to give to workers if there wasn't an imbalance to begin with. Even farmers sustaining their own land have to pay workers to harvest.
> whether or not you worked "hard enough" is judged by other people
This IMO is a personal failure. Others don't determine whether I'm satisfied with my work, I do. I'm proud of my work even if others don't care for it.
> not the entity responsible for putting humans (and therefore you) on the planet in the first place--you're already here so you obviously are supposed to be here, otherwise you wouldn't be
There is no entity responsible, just like there is no reason for 'being here'. Your parents are to thank for raising you, but it could have just as well been other parents or another child! Our lives are a gift we're lucky to experience and we should enjoy it to the fullest on our own terms. If work fulfills you, great. If it doesn't, then do something else.
I really dislike people putting their value systems on others, especially around these kinds of topics. Telling people that what they think is valuable is in fact not is akin to telling people to believe in your faith, or how to raise their kids, etc.
Edit: Also curious why you would create a throwaway for this kind of opinion.
In general, depending on work for one's ultimate meaning is dumb because whether or not you worked "hard enough" is judged by other people, not the entity responsible for putting humans (and therefore you) on the planet in the first place--you're already here so you obviously are supposed to be here, otherwise you wouldn't be. Good work makes you deserve to be among others but it can't make you deserve to exist on the planet.