If you ever played a Williams Bally/Midway pinball machine from the 1990s dot-matrix era (Addams Family, Twilight Zone, Attack from Mars, Medieval Madness, etc), all of the artwork and animation for those displays was done entirely by hand in Deluxe Paint Animation for MSDOS.

The features like stenciling and animbrush were incredibly powerful. And with a little bit of extra software the exported files could be converted directly into a format for the game software to use.