Everything I know, I learned from /r/churning. Although it can be pretty intimidating as a newbie; I was a lurker for a ~year before I was comfortable enough to start hitting SUBs.
As far as general advice, many people acquire Chase UR points predominantly for Hyatt and acquire Amex MR predominantly for flights. If you're in 2 player mode then you earn points a lot faster because you can refer each other.
It's not trivial to do. You have to save rewards points, learn transfer partners (and their booking sites), and be willing to book ~330 days in advance for certain flights.