See if you’re able to read the original Yamanaka iPS paper here. https://www.cell.com/cell/fulltext/S0092-8674(06)00976-7

I read this as an undergrad and had a blast (inside joke lol). I am considering starting a YouTube channel explaining such breakthroughs while going through the original research. If you’re interested I’ll ping you as focus group when I have some!

FWIW: BLAST: Basic Local Alignment Search Tool https://blast.ncbi.nlm.nih.gov/Blast.cgi

2017 lecture by Shinya Yamanaka[0] is really good, much easier to digest too.

[0] - https://youtube.com/watch?v=PTkCDDUbsBc

I read that one in undergrad, it's a great paper.

I would love to watch your channel!

I’ll make sure to invite you then :)

Crazy that it has only been cited about 2000 times over 20 years. Surprising given its impact.

This is an example where even citations fail to recognise significant papers.

The Doudna Charpentier paper, by contrast, has been cited 17k times and publishes only 12 years ago.

As a fun exercise, the journal immunity should provide the reviewer comments to see how things have changed in light of 20 years.

You might like https://fermatslibrary.com/

You can get a rough idea with the right use of chatgpt and Wikipedia while reading any paper, you should give it a try anyway.