I wouldn't mind working remote if my commute is walkable. I purposely live in Boston to have access to the T, but many companies in Boston are opening up offices in Seaport which is the most awkward place to get to using public transit.
The issue is that most offices (especially the bio/chemistry ones) are at the far end, also the silver line blows; unless your office is less than a one mile radius (even then depending on the street it can be painful) it's just a bad time.