The thing I'm trying to understand is whether Johnson & Johnson and AstraZeneca are meaningfully different. All the media just assumes they are (until proven equivalent), but is the genetic code publicly known so we can compare? The Pfizer and Moderna ones are extremely similar. Now, I imagine the adenovirus ones have an order of magnitude more genetic material, but is the code publicly know to compare?
As far as I can tell, they both should have been approved ages ago, if only to depress prices and get more redundancy.
J&J uses a very rare human adenovirus, AZ uses a more common chimpanzee adenovirus. J&J also has the so-called 2PP modification on the Spike protein compared with the AZ vaccine. Good writeup here: https://berthub.eu/articles/posts/genetic-code-of-covid-19-v...
One difference is that J&J has been tested for only one shot and AZ is tested for two shots. Also the amount of vaccin you get shot in your arm could be different. The clotting incidents between the two are certainly different, AZ has much more at the moment.
That’s not the difference the parent is asking about. He’s asking if the adenovirus based vaccines available are meaningfully different.
Reaching beyond the parent’s words, both AstraZeneca and J&J have now had issues with blood clots. If it’s a similar formulation then perhaps you’ve found something and Adenovirus vaccines with a different formulation are unaffected. If they’re very different then perhaps other variations of Adenovirus vaccines need more attention.
> whether Johnson & Johnson and AstraZeneca are meaningfully different
Grammatically, that asks about the difference between J&J & AZ. Your response instead compared them collectively to the mRNA vaccines, rather than comparing them to each other. Thus the response saying "[t]hat’s not the difference the parent is asking about."
The thing I'm trying to understand is whether Johnson & Johnson and AstraZeneca are meaningfully different. All the media just assumes they are (until proven equivalent), but is the genetic code publicly known so we can compare? The Pfizer and Moderna ones are extremely similar. Now, I imagine the adenovirus ones have an order of magnitude more genetic material, but is the code publicly know to compare?
As far as I can tell, they both should have been approved ages ago, if only to depress prices and get more redundancy.