I also just finished a four-and-a-half-hour defence of modern physics by Sean Carroll which has some really good counterarguments in it, as well as a whirlwind history of the last century in physics.
https://www.preposterousuniverse.com/podcast/2023/07/31/245-...
I am conscious of the irony of responding to this post by posting podcasts.
On guitar in fourths tuning, you only need to learn each interval and chord shape once, compared to multiple permutations in standard tuning. Not sure how much difference this makes over the long run as another poster pointed out, but for me it made the process seem much less overwhelming and motivated me to start learning how to make my own chord voicings, which is something I wouldn't have done in standard tuning.
> Not sure how much difference this makes over the long run
I tune in all fourths as well. For me it has made a huge difference since I made the jump some years ago. Putting voicings, patterns, etc., into muscular memory is faster and a lot less work. For my purposes, it makes the instrument more intuitive with a better ear-hand connection. Even very advanced players trip on the G-B strings oddity (with things like playing a fast, angular melody on different string sets, without preparation, for example).
It's really nice to play a scale, come to the octave, slide, and keep on playing the same shape across the higher strings. It's made the fretboard feel a lot more transparent to me.
I haven't played a linear isomorphic keyboard, but I do play guitar with an isomorphic tuning (EADGCF) and I have an Intuitive Instruments Exquis, which is a hex-grid. I feel like melody makes more sense linearly but harmony makes more sense in 2D.
I use all-fourths tuning on guitar (EADGCF) which makes the fretboard isometric.
You lose some idiomatic guitar vocabulary, but if you don't care about that you gain the ability to construct your own chord voicings much more easily, and only need to remember one fingering for each chord instead of three.
I tried to install it recently to a linux container running on proxmox. I gave up after half an hour because it requires a ton of PHP dependencies and there's no instructions or script provided to install them. I guess if you use the docker version it should be easier, but that wasn't an option for me.
https://github.com/renoise/pattrns