Terrible pop sci title that makes the work sound a bigger deal than it is. I thought that evolution of cancer under drug treatment would be described. But a more accurate title would be, Computer simulations of proteins show molecular mechanism of particular resistance mutations to imatinib that were previously characterized to increase ligand dissociation kinetics.
That is, certain mutations in the protein that the drug imatinib inhibits enable cancer cells to be more resistant to the drug. A previous experimental study by the researchers found that these mutations increase the rate of drug unbinding from the protein. The study here describes computer simulations of the protein and explains why the mutations lead to increased dissociation kinetics. An advanced algorithm was used to sample ligand unbinding events in simulation.
What a strange, backward take-away. This 84% will include people who watch 15 minutes of TV before going to bed, or people who put on the news while they're getting ready in the morning. Not sure why you would take it to assume people are watching 12 hours of TV on vacation.
I know you mean lifespan if left to die of natural causes, but To be honest the “natural lifespan” of a cow is 0 years and the average life of a cow is a picnic compared to the hardships faced by a comparable natural animal in the wild.
Edit: clarified distinction in understood meaning.
I don’t have AirPods but this sometimes happens to me when I turn off my Bluetooth headphones. Usually it’s Spotify that begins playing on my computer. I agree that google searching has been unhelpful.
I use org mode by having a single file and using it as a notebook/journal. I use todos to mark important entries.
I’m comfortable with org mode operations and formatting although I don’t know how to use drawers or properties or what’s the point of archiving. I like using org-ref, and I see a version of that has been added officially this version.
I never learned a more clever way of using org mode. Any tips or guides?
Archiving declutters my org files. I could delete things, but archiving saves me from screwing up, and it's basically for free.
No need to use drawers or properties necessarily. I've got into Properties mostly through realising the incredible power of org-columns, which can turn an org file into something like a spreadsheet at the drop of a C-c C-x C-c. If I'm trying to keep track on the status of a big project, that can be really handy, showing the status of each entry, effort estimates, time spent on them, and really whatever else. (I use this to produce Gantt charts with org-taskjuggler.) And then a C-c C-c and you're back in a plain-old org text file.
But the use case is not the middle of the night but perhaps during evening rush hour where it gets dark after 5 PM in the winter, and a storm began in the afternoon.
The first idea seems like it would require a lot a lot of data stored in the car. Is it feasible? And even so, to be that dependent on matching up with existing pre-mapped data suggests a system that would be quite slow to roll out across a country.
> "I also really like timetables and I like the logistics of putting things together."
I enjoy that too. It's also essential if you don't have a car. I think it's a shame that Amtrak no longer has timetables for download. Maybe it's to hide the sad fact that there are only 10-15 trains per day in one direction on the northeast corridor.
No it just has to be pressurized in order to stay in liquid state. The pressures involved at normal ambient temperatures are less than 300 psi, which is not extreme. Scuba tanks, for example, handle pressures of 3000 psi or sometimes more.
That is, certain mutations in the protein that the drug imatinib inhibits enable cancer cells to be more resistant to the drug. A previous experimental study by the researchers found that these mutations increase the rate of drug unbinding from the protein. The study here describes computer simulations of the protein and explains why the mutations lead to increased dissociation kinetics. An advanced algorithm was used to sample ligand unbinding events in simulation.