I have couple of websites. The first one[0] is done with basic Bootstrap. Second[1], I bought BootStrap theme from WrapBootStrap and reducing it to my needs.
Apart from this, the main issue is designing logos and graphics. Eventhough it takes time, I somehow do it myself(with GIMP) and enjoy it as well :)
The upcoming Ghost[1] blogging platform/tool has side by side post editor that supports Markdown on left and visual formatting on right. This should make it easier to learn Markdown syntax.
Also, I believe, Markdown is the best option for generating formatted content on touch based devices.
Prose.io has kind of a hybrid markdown editor (I think it's WYSIWYM?). It has markdown syntax highlighting that happens to look similar to the final output, though the markdown tags are still displayed. They also have a toolbar, which is used like a regular WYSIWYG toolbar, but generates mardown tags.